Monday, April 29, 2013

New conservative lobbying push for gay marriage

ST. PAUL, Minn. (AP) ? A national group of prominent GOP donors that supports gay marriage is pouring new money into lobbying efforts to get Republican lawmakers to vote to make it legal.

American Unity PAC was formed last year to lend financial support to Republicans who bucked the party's longstanding opposition to gay marriage. Its founders are launching a new lobbying organization, American Unity Fund, and already have spent more than $250,000 in Minnesota, where the Legislature could vote on the issue as early as next week.

The group has spent $500,000 on lobbying since last month, including efforts in Rhode Island, Delaware, Indiana, West Virginia and Utah.

Billionaire hedge fund manager and Republican donor Paul Singer launched American Unity PAC. The lobbying effort is the next phase as the push for gay marriage spreads to more states, spokesman Jeff Cook-McCormac told The Associated Press.

"What you have is this network of influential Republicans who really want to see the party embrace the freedom to marry, and believe it's not only the right thing for the country but also good politics," Cook-McCormac said.

In Minnesota, the money has gone to state groups that are lobbying Republican lawmakers and for polling on gay marriage in a handful of suburban districts held by Republicans. So far, only one Minnesota Republican lawmaker has committed to voting to legalize gay marriage: Sen. Branden Petersen, of Andover.

"I think there will be some more. There are legislators out there that are struggling with this," said Carl Kuhl, a former political aide to former GOP Sen. Norm Coleman and Republican gubernatorial candidate Tom Emmer. Kuhl's public affairs firm is contracted by Minnesotans United, the lead lobby group for gay marriage in Minnesota and main recipient of American Unity's Minnesota spending.

Gay marriage's fate in Minnesota may rest with the House, where support is seen as shakier than in the Senate. A handful of votes from Republicans could put it over the top. Nearly two dozen House Republicans represent more socially moderate suburbs and might be candidates to vote yes.

House Speaker Paul Thissen, DFL-Minneapolis, said he has encouraged advocates of the marriage bill to round up Republican votes, if nothing else than to send a message to Minnesota residents that it's not a partisan proposition. But that will be politically risky; the main opposition group to same-sex marriage, Minnesota for Marriage, has said it will seek consequences for Republicans who stray on gay marriage.

Part of American Unity PAC's original mission was to spend money on behalf of Republican gay marriage supporters. Many GOP lawmakers have faced primary challenges funded in part by anti-gay marriage groups such as the National Organization for Marriage, which argue that the lawmakers had betrayed the party's core principles.

Since forming the lobby group last month, American Unity also spent money to win over Republican lawmakers in Rhode Island, where last week all five Republicans in the state Senate jumped on the gay marriage bandwagon. Rhode Island is on track to legalize gay marriage by next week, which would make it the 11th U.S. state where gay marriage is legal.

There are also plans to lobby federal lawmakers on gay rights issues.

"We intend to work on this effort until every American citizen is treated equally under the law," Cook-McCormac said. Other wealthy, traditionally Republican donors giving money to the group include Seth Klarman, David Herro and Cliff Asness.

Though only one current GOP officeholder in Minnesota is on record supporting gay marriage, a handful of prominent Republicans have spoken out in favor of it. They include former state auditor Pat Anderson and Brian McClung, who was spokesman for former Gov. Tim Pawlenty. Prominent Republican donors including former politician Wheelock Whitney and businesswoman Marilyn Carlson Nelson have also lent support and donated money.

Since it first formed to campaign against last fall's gay marriage ban and then shifted to pushing for its legalization at the Capitol, Minnesotans United has been building Republican alliances, hiring multiple lobbyists with Republican ties.

Source: http://news.yahoo.com/conservative-lobbying-push-gay-marriage-050802280.html

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Share the vision of joining in | Surf Coast Times ? Bellarine Times ...

Patsy Barton

Legally blind Patsy Barton, 83, is helped by Vision Australia support worker Marg Tozer to make a woollen scarf.

Vision Australia will showcase its services at an open day in Geelong next month. The five-hour event will promote the non-profit organisation?s services.

Vision Australia encourages those who are blind, sighted or have low vision to participate to their potential within their community. There will be service information, displays, demonstrations, clients, staff and volunteers in Vision Australia who will be available for questions.

Vision Australia information library services will be present to discuss talking books, magazines and other information. Displays include recreation options, adaptive technology, orientation and mobility, Seeing Eye Dogs Australia, orthoptics and children?s services.
Visitors can view the Geelong Vision Australia Radio studio.

This broadcasts on 99.5FM ? where volunteers work to provide a very valuable service to people who are blind, have low vision or are print handicapped.

The Geelong Macular Support Group will meet for their ?bring your own lunch? meeting from noon-12.30pm and the door is open for anyone interested to join them. From 12.45-1.45pm, there will be a presentation on DisabilityCare Australia (the new name for the National Disability Insurance Scheme), followed by a presentation on adaptive technology.

The Vision Australia open day will be held at 79 High Street, Belmont from 10am-3pm on May 3. For more information, call Noel on 5249 2701.

Source: http://www.surfcoasttimes.com.au/news/community/2013/04/29/share-the-vision-of-joining-in/

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Sunday, April 28, 2013

Two policemen shot as new Italy government sworn in

By Gavin Jones and Roberto Landucci

ROME (Reuters) - Enrico Letta was sworn in as Italy's new prime minister on Sunday and immediately faced an emergency after an unemployed man shot two police officers outside his office.

The 49 year-old gunman, from the poor southern region of Calabria, told investigators he had planned to attack politicians but had found none within range.

One of the officers was shot in the neck, hitting his spinal cord, and he was in a serious condition, surgeons said. The other was shot in the leg.

In a surreal scene, outgoing Prime Minister Mario Monti received the official trumpet salute in the courtyard of the renaissance Chigi palace before walking across the cordoned-off square, past police crouching over the scene of the shooting, looking for evidence.

There were immediate calls for parties to try to calm a heated public mood that has been exacerbated by deep political divisions as Italy languishes in its longest recession for 20 years and has been without a proper government for months.

"Our politicians have to start providing solutions to the social crisis and to peoples' needs because the crisis transforms victims into killers like the man who shot today," said lower house speaker Laura Boldrini.

"There's a social emergency that needs answers and our politicians have to start giving them."

Letta, 46, who will set out his program in parliament on Monday, has said his first task will be to tackle the economy which has contracted for six consecutive quarters and pushed youth unemployment close to 40 percent.

Official data this month showed that alongside Italy's 2.7 million officially unemployed in 2012, there were 3 million more who were so demoralized they had given up the search for work, a far higher number than in any other EU country.

The gunman's home town of Rosarno has a jobless rate far above the national average and is renowned for the activities of the local mafia, the 'Ndrangheta, and riots by African immigrants paid a pittance to collect the local fruit harvest.

"SHOOT ME"

Having fired several shots at the police on duty outside the prime minister's office, the man, dressed in a suit, shouted "shoot me, shoot me" to other officers nearby, police said.

Letta, on the right of his center-left Democratic Party (PD), ended two months of stalemate that followed an inconclusive general election by uniting political rivals in a broad coalition government.

The mix of center-right and center-left politicians and unaffiliated technocrats has a record number of seven female ministers and is made up by relative youngsters in an attempt to respond to public disillusion with the political elite.

But the continued risk of political instability was spelled out by an ally of center-right leader Silvio Berlusconi.

Renato Brunetta, lower house leader of Berlusconi's People of Freedom party (PDL), said the government would fall unless Letta promised in his maiden speech to swiftly abolish an unpopular housing tax and repay the 2012 levy to taxpayers.

"If the prime minister doesn't make this precise commitment we will not give him our support in the vote of confidence," following the speech, Brunetta told daily Il Messaggero.

He said that during negotiations for the formation of the government Letta had "given his word" on the abolition and repayment of the tax, which would gouge an 8-billion-euro hole in public accounts.

New Economy Minister Fabrizio Saccomanni, formerly deputy governor of Italy's central bank, said he wanted to cut public spending and taxes, but made no reference to the housing tax.

DISCREDITED

In the election, Italians vented their anger at a discredited political class by giving 25 percent of votes to the anti-establishment 5-Star Movement led by former comic Beppe Grillo, which refused to join any coalition.

Divisions have deepened since the vote, with millions of center-left voters upset, first by a bad split inside the PD and then by the party's decision to govern with Berlusconi after its leadership, including Letta, had ruled out that possibility.

Berlusconi, widely written off after being forced from office in 2011 at the height of a debt crisis, is now a vital part of the ruling majority and has placed several ministers in the cabinet, including the PDL's national secretary Angelino Alfano as deputy prime minister and interior minister.

Recent polls give him a lead of between five and eight percentage points over the center-left, and many commentators believe he may bring down the government as soon as he is fully confident of winning an election.

(Additional reporting by James Mackenzie and Antonella Cinelli; Editing by Robin Pomeroy)

Source: http://news.yahoo.com/italian-government-under-enrico-letta-sworn-094720376.html

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Thursday, April 25, 2013

Officials: Dead bomber name in terrorism database

(AP) ? The CIA added the name of the dead Boston Marathon bombing suspect to a U.S. government terrorist database 18 months before the deadly explosions, U.S. officials told The Associated Press on Wednesday.

The CIA's request came about six months after the FBI investigated Tamerlan Tsarnaev, also at the Russian government's request, but the FBI found no ties to terrorism, officials said.

The new disclosure was significant because officials have said the U.S. intelligence community had no information leading up to the April 15 bombings that killed three people and injured more than 260 others. That one of the bomber's name was in a terrorism database for 18 months before the attack was expected to drive congressional inquiries about whether the U.S. government adequately investigated tips from Russia that Tsarnaev posed a security threat.

In late September 2011, the CIA received information from the Russian government about Tsarnaev, who died Friday in a police shootout. In March 2011, the FBI received nearly identical information as the CIA, according to officials briefed on the investigation. The officials spoke on condition of anonymity because they were not authorized to speak publicly about the ongoing case.

The massive database, known as the Terrorist Identities Datamart Environment, is managed by the National Counterterrorism Center and feeds into terror watch lists like the one that bans known or suspected terrorists from getting on airplanes.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-24-Boston%20Marathon-Washington/id-8b829599fda94a4481aa30fccabecc29

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Memphis? Gasol wins NBA defensive player honors

Memphis Grizzlies center Marc Gasol, of Spain, yells to referee Mike Callahan during the second half of Game 2 of a first-round NBA basketball playoff series, Monday, April 22, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Memphis Grizzlies center Marc Gasol, of Spain, yells to referee Mike Callahan during the second half of Game 2 of a first-round NBA basketball playoff series, Monday, April 22, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

(AP) ? Grizzlies center Marc Gasol has won his first NBA Defensive Player of the Year award after anchoring the league's stingiest defense.

The NBA announced Wednesday that Gasol received 212 points and 30 first-place votes to edge Miami's LeBron James, who had 149 points and 18 first-place votes.

The 7-foot-1 Spaniard averaged 1.7 blocks and 1.0 steals for a Memphis defense that allowed a league-best 88.7 points per game.

Oklahoma City's Serge Ibaka was third with 122 points and 14 first-place votes. The 28-year-old Gasol becomes the first Grizzlies player to earn defensive player honors.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-24-BKN-NBA-Defensive-Player-Award/id-6f7d110a08e049d48b2693c057d6eda3

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U.S. sues Novartis, alleging kickbacks to pharmacies

By Bernard Vaughan and Jonathan Stempel

(Reuters) - The U.S. government filed a civil fraud lawsuit against Novartis AG on Tuesday, accusing a unit of the Swiss drug maker of causing the Medicare and Medicaid programs to pay tens of millions of dollars in reimbursements based on fraudulent, kickback-tainted claims.

U.S. Attorney Preet Bharara in Manhattan said Novartis Pharmaceuticals Corp had since 2005 induced at least 20 pharmacies to switch thousands of kidney transplant patients to its immunosuppressant drug Myfortic from competitors' drugs, in exchange for kickbacks disguised as rebates and discounts.

He said Novartis tried to conceal the scheme by omitting the agreements from rebate and discount contracts with pharmacies.

In one alleged case, Novartis offered a Los Angeles pharmacist a "bonus" rebate of 5 percent of that pharmacist's annual Myfortic sales, or several hundred thousand dollars, to switch as many as 1,000 patients to Myfortic.

"Novartis co-opted the independence of certain pharmacists and turned them into salespeople," Bharara said in a statement.

The lawsuit was filed in U.S. District Court in Manhattan, and seeks civil penalties and triple damages from Novartis for violating the federal False Claims Act.

Novartis disputes the claims and will defend itself, spokeswoman Julie Masow said in an email.

Novartis is "committed to high standards of ethical business conduct and regulatory compliance in the sale and marketing of our products," Masow said.

Myfortic net sales totaled $579 million in 2012, up 12 percent from a year earlier, according to Novartis' annual report. The Novartis Pharmaceuticals unit has offices in East Hanover, New Jersey.

In his announcement, Bharara called Novartis a "repeat offender," referring to a settlement of health care fraud charges based on kickbacks less than three years ago.

Novartis in September of 2010 agreed to pay $422.5 million to resolve criminal and civil liability over its marketing of several drugs, including the epilepsy drug Trileptal. (http://www.justice.gov/opa/pr/2010/September/10-civ-1102.html)

The company violated a federal anti-kickback statute, "choosing instead to put sales growth and profits before its duty to comply with federal law," according to the new complaint.

The federal anti-kickback statute prohibits paying people to buy drugs or services that Medicare, Medicaid or other federal healthcare programs cover, according to the complaint.

The scheme has been highly lucrative for Novartis, according to the complaint, resulting in "rapid, sometimes exponential growth in Myfortic sales."

A pharmacy in Arkansas, for example, increased its annual sales of the drug to more than $1 million from $100,000 over four years, according to the complaint.

The lawsuit also claims a Novartis account manager admitted the kickback scheme generates "an ongoing stream of revenue" for Novartis "as long as the patient is still living and using (Myfortic)."

These types of cases "are one of the highest priorities of the FBI's health care fraud program," FBI Assistant Director Ronald Hosko said in a statement.

The case is U.S. v. Novartis Pharmaceuticals Corp, U.S. District Court, Southern District of New York, No. 11-08196.

(Reporting by Jonathan Stempel and Bernard Vaughan in New York; Editing by Gary Hill, David Gregorio and Tim Dobbyn)

Source: http://news.yahoo.com/u-sues-novartis-alleging-kickbacks-pharmacies-010252156--finance.html

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Wednesday, April 24, 2013

Genetic circuit allows both individual freedom, collective good

Apr. 22, 2013 ? Individual freedom and social responsibility may sound like humanistic concepts, but an investigation of the genetic circuitry of bacteria suggests that even the simplest creatures can make difficult choices that strike a balance between selflessness and selfishness.

In a study published online this week in the journal Scientific Reports, researchers from Rice University's Center for Theoretical Biological Physics (CTBP) and colleagues from Tel Aviv University and Harvard Medical School show how sophisticated genetic circuits allow an individual bacterium within a colony to act on its own while also ensuring that the colony pulls together in hard times.

"Our findings suggest new principles for collective decisions that allow both random behavior by individuals and nonrandom outcomes for the population as a whole," said study co-author Eshel Ben-Jacob, a senior investigator at CTBP and adjunct professor of biochemistry and cell biology at Rice. "These new principles could be broadly applicable, from the study of cancer metastasis to the study of collective decisions by humans during times of stress."

Some species of bacteria live in complex colonies that can contain millions of individual cells. An increasing body of research on bacterial colonies has found that members often cooperate -- even to the point of sacrificing their lives -- for the survival of their colony. For example, in response to extreme stress, such as starvation, most of the individual cells in a colony of the bacteria Bacillus subtilis will form spores. Spore formation is a drastic choice because it requires the cell to kill itself to encase a copy of its genetic code in a tough, impervious shell. Though the living cell dies, the spore acts as a kind of time capsule that allows the organism to re-emerge into the world of the living when conditions improve.

"This time-travel strategy of waiting and safeguarding a copy of the DNA in the spore ensures the survival of the colony," Ben-Jacob said. "But there are other, less desperate options that B. subtilis can take to respond to stress. Some of these cells turn into highly mobile food seekers. Others turn cannibalistic, and about 10 percent enter a state called 'competence' in which they bide their time and bet on present conditions to improve."

Scientists have long been curious about how bacteria decide which of these paths to pursue. Years of studies have determined that each individual constantly senses its environment and continuously sends out chemical signals to communicate with its neighbors about the choices it is making. Experimental studies have revealed dozens of regulatory genes, signaling proteins and other genetic tools that cells use to gather information and communicate with one another.

"Bacteria don't hide their intentions from their peers in the colony," said study co-author Jos? Onuchic, co-director of CTBP, Rice's Harry C. and Olga K. Wiess Professor of Physics and Astronomy and professor of chemistry and biochemistry and cell biology. "They don't evade or lie, but rather communicate their intentions by sending chemical messages among themselves."

Individual bacteria weigh their decisions carefully, taking into account the stress they are facing, the situation of their peers, the statistics of how many cells are sporulating and how many are choosing competence, Onuchic said. Each bacterium in the colony communicates via chemical "tweets" and performs a sophisticated decision-making process using a specialized complex gene network composed of many genes connected via complex circuitry. Taking a physics approach, Onuchic, Ben-Jacob and study co-authors Mingyang Lu, Daniel Schultz and Trevor Stavropoulos investigated the interplay between two components of the circuitry -- a timer that determines when sporulation occurs and a two-way switch that causes the cell to choose competence over sporulation.

"We found that the sporulation timer and the competence switch work in a coordinated fashion, but the interplay is complex because the two circuits are affected very differently by noise," said Schultz, a postdoctoral fellow at Harvard Medical School and a former graduate student at CTBP.

Noise results from random fluctuations in a signal; every circuit -- whether genetic or electronic -- responds to noise in its own way. In the case of B. subtilis, noise is undesirable in the sporulation timer but is a necessity for the proper function of the competence switch, the researchers said.

"Our study explains how the two opposite noise requirements can be satisfied in the decision circuitry in B. subtilis," Onuchic said. "The circuits have a special capacity for noise management that allows each individual bacterium to determine its fate by 'playing dice with controlled odds.'"

Ben-Jacob said the timer has an internal clock that is controlled by cell stress. The noise-intolerant timer typically keeps the competence switch closed, but when the cell is exposed to stress over a long period of time, the timer activates a decision gate that opens brief "windows of opportunity" in which the competence switch can be flipped.

Thanks to its architecture, the gate oscillates during the window of opportunity, he said. At each oscillation, the switch opens for a short time and grants the cell a short window in which it can use noise as a "roll of the dice" to decide whether to escape into competence.

"The ingenuity is that at each oscillation the cell also sends 'chemical tweets' to inform the other cells about its stress and attempt to escape," said Ben-Jacob, the Maguy-Glass Professor in Physics of Complex Systems and professor of physics and astronomy at Tel Aviv University. "The tweets sent by others help regulate the circuits of their neighbors and guarantee that no more than a specific fraction of cells within the colony will enter into competence."

Onuchic said the decision-making principles revealed in the study could have implications for synthetic biologists who wish to incorporate sophisticated decision systems as well as for cancer researchers who are interested in exploring the decision-making processes that cancer cells use in choosing to become dormant or to metastasize.

"This represents a real fusion of ideas from statistical physics and biology," he said.

Lu is a postdoctoral research fellow at CTBP and Stavropoulos is a former graduate student and CTBP fellow at the University of California, San Diego. The research was funded by the National Science Foundation, the Cancer Prevention and Research Institute of Texas and the Tauber Family Foundation.

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The above story is reprinted from materials provided by Rice University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Daniel Schultz, Mingyang Lu, Trevor Stavropoulos, Jose' Onuchic, Eshel Ben-Jacob. Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate. Scientific Reports, 2013; 3 DOI: 10.1038/srep01668

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/gz6J2r-SJZQ/130422123042.htm

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Tuesday, April 23, 2013

Why Ezine Advertising Works. | Bring The Fresh for Online Income

Everyone involved in online marketing knows that traffic is the life blood of any online business. But what a lot of people may not know is that not all traffic out there in the big wide world of the internet is good traffic. It is quite possible for you to work hard and/or pay out good money to get tons of traffic to your web site and not make a dime in sales, if it is not the right kind of traffic. What you need is highly targeted traffic based on some knowledge of your target audience?s previous behaviour patterns. In other words, people that you know are likely to be interested in what you have to offer because they have demonstrated their inclination through their previous actions, represent what might be called ?good? traffic. Such ?good? traffic it is what you get with ezine advertising.

What is an Ezine?

An ezine is an electronic magazine or newsletter that is usually delivered to subscribers via email, with the frequency of delivery ranging from daily, to as little as once or twice a month. In signing up to an ezine, subscribers effectively give the publisher permission to send them the information contained in the ezine. The power of ezine advertising therefore lies in the fact that it is highly targeted. This means that you know before placing an ad in a particular ezine that the readers are already predisposed to receive the information and are therefore likely to be interested in whatever you have to offer.

Why Ezine Advertising is Successful

The key to successful ezine advertising is to match your offer to the content of the ezine. When this is done correctly, it is the fastest way of getting targeted traffic because the ezine you choose is already in regular contact with the audience you want to reach. Now, when you enter the scene with your offer, delivered in the form of, say, a solo ad, the fact that the ezine publisher has seen fit to publish your ad is a sort of endorsement of your offer by the publisher, which makes the readers of the ezine more receptive to it. You are in effect piggy backing the credibility of the ezine publisher who already has a level of trust from the readership of the ezine.

Another reason why ezine advertising is successful is because ezines have a growing readership. They take on new subscribers daily, thus increasing the reach of your advert. In addition, people who do not buy first time on seeing your ad ? they may wish to mull over a decision or decide to do some further research before making the purchase ? will often be prompted to make the purchase by seeing the ad several times.

Choosing the Right Ezine for Maximum Effect.

A search of the internet will quickly reveal that there are literally thousands of Ezines to choose from when looking to place an ad. They range from what might be termed high end ezines that will send your offer out to millions of subscribers for a small fortune, to much smaller ezines with less than one thousand subscribers.

Your choice of ezine will therefore to a large extent be determined by your budget. However, it is more important when choosing an ezine to make sure it targets the right audience. For example, if you wanted to promote a dieting product, it might be tempting to place an ad in a large ?Entertainment? ezine, since no doubt there will be some subscribers to the ?Entertainment? ezine who are interested in losing weight. However, you would be far better off placing your advert in a much smaller ?Health & Fitness? ezine since subscribers to the latter are already primed to receive weight loss information.

Source: http://bringthefreshonlineincome.com/why-ezine-advertising-works/

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Senior Sudanese delegation invited to Washington

(AP) ? The Obama administration is preparing to welcome a senior Sudanese delegation to the United States for some rare highest-level diplomacy between the countries.

State Department spokeswoman Hilary Renner says Sudanese presidential adviser Nafie Ali Nafie and other officials have accepted an invitation to Washington for a "candid discussion on the conflicts and humanitarian crises within Sudan."

She says no date has yet been fixed.

But it has been years since the U.S. received such a high-level delegation from Sudan, which Washington has considered a state sponsor of terrorism since 1993.

The U.S. also blames the African country for atrocities in Darfur and along the border with South Sudan.

Renner said Tuesday the U.S. remains concerned about Sudan's "aerial bombardment of civilian areas," human trafficking and other rights issues.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-23-US-US-Sudan/id-0480fe7882044ee0966fb38ac578d919

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Saturday, April 13, 2013

'Matilda' Gets Rave Reviews, Called Best Musical Since 'Lion King'

By Brent Lang

LOS ANGELES (TheWrap.com) - "Matilda the Musical" announced itself as the production to beat at the box office and perhaps at the Tony Awards this season.

The West End transplant, which arrives courtesy of the Royal Shakespeare Theatre, was a smash in London when it debuted in 2011. And critics believe little was lost when it opened Thursday night on Broadway. Australian songwriter Tim Minchin is the allusion-spouting phenom behind the witty score and, with last night's bundle of raves and a recent profile in the New Yorker, he looks ready to be the toast of Broadway.

Critics searched for fresh superlatives to describe the production, which adapts Roald Dahl's children's book about a bookish young girl rebelling against her dim-bulb parents and tyrannical headmistress. The production keeps intact the Englishness that was scrubbed clean in Danny DeVito's 1996 film adaptation.

Richard Zoglin praised the production as a bold step forward for the musical genre, writing inTime that Minchin's score is less ostentatious and more organic than many of the stale Tin Pan Alley knock-offs cropping up around Times Square. This one will stand the test of time, he concluded.

"It would be easy to call it the best British musical since 'Billy Elliot,' but that, I'm afraid, would be underselling it," Zoglin writes. "You have to go back to 'The Lion King' to find a show with as much invention, spirit and genre-redefining verve. After plugging through years of slick but workmanlike musicals, crowd-pleasing song cycles and formulaic spirit-lifters (latest example: 'Kinky Boots'), Matilda seems to clear away the deadwood and announce a fresh start for the Broadway musical."

Elisabeth Vincentelli was equally effusive in her New York Post review, writing that "Matilda" more than lives up to its advance hype and praising the production for staying true to Dahl's black humor.

"Once in a blue moon, a show comes out blazing and restores your faith in Broadway. 'Matilda The Musical' is that show," Vincentelli writes.

In the New York Times, Ben Brantley, who can be ornery in his assessments, urged theater lovers to barricade the Shubert Theatre where "Matilda" is currently playing. He found little to fault in the performances, the choreography or Minchin's score.

"In the first act Matilda sings, 'If you're stuck in your story and want to get out/ You don't have to cry and you don't have to shout,'" Brantley writes. "'You just have to use your imagination and think everything through carefully, so it's all of a piece.' That's what the creators of 'Matilda' have done. Such strategy should be obvious. But in the current landscape of Broadway it's applied rarely enough to make this show feel truly revolutionary."

Chris Jones of the Chicago Tribune called "Matilda," the best family musical in years," while also calling it a "grand cultural experience."

"At the international box office and in likely future long runs in Chicago and elsewhere, the key to the surely huge success of 'Matilda' will be in its subtle linkage to the Harry Potter market (another franchise that never has shied from dispensing hard truths to kids), its batting on the side of the girl-nerds who soon will rule the world and not just according to Beyonce, and its reminder of how some of us are old enough to remember when schools did not embrace compassion and kindness," Jones writes.

"And very few of us had the guts or chops of Matilda and her pals. If only."

Thom Geler of Entertainment Weekly offered similar praise for the score, the book and the overall production, albeit with a few more reservations.

"Even gold-star students fall short of perfection, and the same is true of Matilda," Geler writes. "There's a squirm-inducing dip in momentum in the second act, with a longish lull and somewhat repetitive scenes between that growing-up song and the anarchic, 'Spring Awakening'-like final number, 'Revolting Children.' And that song is one of several whose tongue-twisting lyrics seem like a mouthful for very young performers less trained in enunciation."

Source: http://news.yahoo.com/matilda-gets-rave-reviews-called-best-musical-since-205951421.html

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Molecular hub links obesity, heart disease to high blood pressure

Friday, April 12, 2013

Obesity, heart disease, and high blood pressure (hypertension) are all related, but understanding the molecular pathways that underlie cause and effect is complicated.

A new University of Iowa study identifies a protein within certain brain cells as a communications hub for controlling blood pressure, and suggests that abnormal activation of this protein may be a mechanism that links cardiovascular disease and obesity to elevated blood pressure.

"Cardiovascular diseases are the leading cause of death worldwide, and hypertension is a major cardiovascular risk factor," says Kamal Rahmouni, Ph.D., UI associate professor of pharmacology and internal medicine, and senior study author. "Our study identifies the protein called mTORC1 in the hypothalamus as a key player in the control of blood pressure. Targeting mTORC1 pathways may, therefore, be a promising strategy for the management of cardiovascular risk factors."

The hypothalamus is a small region of the brain that is responsible for maintaining normal function for numerous bodily processes, including blood pressure, body temperature, and glucose levels. Signaling of mTORC1 protein in the hypothalamus has previously been shown to affect food intake and body weight.

The new study, which was published April 2 in the journal Cell Metabolism, shows that the mTORC1 protein is activated by small molecules and hormones that are associated with obesity and cardiovascular disease, and this activation leads to dramatic increases in blood pressure.

Leucine is an amino acid that we get from food, which is known to activate mTORC1. The UI researchers showed that activating mTORC1 in rat brains with leucine increased activity in the nerves that connect the brain to the kidney, an important organ in blood pressure control. The increased nerve activity was accompanied by a rise in blood pressure. Conversely, blocking this mTORC1 activation significantly blunted leucine's blood pressure-raising effect.

This finding may have direct clinical relevance as elevated levels of leucine have been correlated with an increased risk of high blood pressure in patients with cardiovascular disease.

"Our new study suggests a mechanism by which leucine in the bloodstream might increase blood pressure," Rahmouni says.

Previous work has also suggested that mTORC1 is a signaling hub for leptin, a hormone produced by fat cells, which has been implicated in obesity-related hypertension.

Rahmouni and his colleagues showed that leptin activates mTORC1 in a specific part of the hypothalamus causing increased nerve activity and a rise in blood pressure. These effects are blocked by inhibiting activation of mTORC1.

"Our study shows that when this protein is either activated or inhibited in a very specific manner, it can cause dramatic changes in blood pressure," Rahmouni says. "Given the importance of this protein for the control of blood pressure, any abnormality in its activity might explain the hypertension associated with certain conditions like obesity and cardiovascular disease."

Rahmouni and his team hope that uncovering the details of the pathways linking mTORC1 activation and high blood pressure might lead to better treatments for high blood pressure in patients with cardiovascular disease and obesity.

###

University of Iowa Health Care: http://www.uihealthcare.com/index.html

Thanks to University of Iowa Health Care for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127730/Molecular_hub_links_obesity__heart_disease_to_high_blood_pressure

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Friday, April 12, 2013

Climate Change in Classrooms: Here Come the New Science Standards

At the center of the newly unveiled Next Generation Science Standards are two controversial, and political, topics?climate change and evolution.

Teams from 26 states and a 41-member writing team spent three years creating the standards that are aimed at creating science education for students in the 21st century.

They were much needed considering the last time science standards came out was in 1996. Additionally, the U.S. doesn?t fair well globally with other countries when it comes to science. That?s why the creators of the new standards looked to similar standards in Singapore, South Korea, and Finland.

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?The NGSS aim to prepare students to be better decision makers about scientific and technical issues and to apply science to their daily lives,? Matt Krehbiel, Science Education Program Consultant of Kansas, said in a release. ?By blending core science knowledge with scientific practices, students are engaged in a more relevant context that deepens their understanding and helps them to build what they need to move forward with their education?whether that's moving on to a four-year college or moving into post-secondary training.?

State school boards still have to vote on the science standards, and that could be where debates begin.

The new standards go beyond science as simply a list of facts and ideas students are expected to memorize. Instead, they cover fewer ideas and use more concepts so students have a deeper understanding. On the climate change front, students will learn that carbon dioxide emissions from burning oil, coal, and gas are causing our planet to warm.

Even still, some say that climate change theory was watered down in the final version of the standards?especially for elementary school students.

Mario Molina, deputy director at the Alliance for Climate Education, told The Guardian that 35 percent of the sections devoted to climate change were cut in response to public comments.

?The basic science of climate change?the greenhouse effect and human contribution to it through burning fossil fuels?is still included in NGSS at the elementary and middle school levels, with high school content extending to practices such as analyzing climate model results and modeling flows of energy through the climate system,? the Alliance for Climate Education said on its blog.

For example, students in kindergarten through fifth grade will develop an understanding of the four disciplinary core ideas: physical sciences; life sciences; earth and space sciences; and engineering, technology, and applications of science.

In middle school, students begin to create relationships about the life, earth, and space sciences by building upon what was taught in the earlier grades. In regards to the planet's history, the standards state that students will ?examine geoscience data in order to understand the processes and events in Earth?s history.?

Students will also examine the "evidence of the factors that have caused the rise in global temperatures over the past century.?

They will make arguments supported by evidence for how a growing human population and consumption impact the Earth?s natural resources. Students will apply principles to design a method for monitoring and minimizing human impact on the environment.

In high school, students will still focus on the same sciences but with analytical thinking.

It's unclear how these 21st century standards will translate when state education boards get involved?even those who had a seat at the table to write them. It is not mandatory that school boards adopt the new standards.

Take Kansas, for example. In 1999, the state board, when adopting science standards, deleted references to evolution from the state guidelines and left the decision about whether to teach evolution up to individual school districts. Other states have also taken similar actions.

The political battle lines are already being drawn.

?It's a victory for progressives and liberals. For us conservatives it's a very bad set of standards,? said Robert Lattimer, president of Citizens for Objective Public Education.

He called the standards ?a very politically correct document put together by elite scientists. It doesn't reflect correct science at all.?

Related Stories on TakePart:

? 'Girls Who Code' Combats the Gender Gap in Computer Sciences

? Mayim Bialik of ?The Big Bang Theory?: Girls Rock Math and Science Too

? Code Red: Why Kids Aren?t Learning Computer Skills


Suzi Parker is an Arkansas-based?political and cultural journalist whose work frequently appears in?The Washington?Post?and?The Christian Science Monitor. She is the?author of two books. @SuziParker | TakePart.com?

Source: http://news.yahoo.com/climate-change-classrooms-come-science-standards-020010786.html

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Teeny Tiny Analog Synthesizers Are the Most Adorable Way to Lay Down Your Jams

Well, these new itty-bitty analog synthesizers from Korg are just so cute I want to gobble them up. And from the demo video above, it sounds like the three Volca series keyboards are lovely little groove machines you might want to use, too. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/StswtS907IU/teeny-tiny-analog-synthesizers-are-the-most-adorable-way-to-lay-down-your-jams

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Thatcher funeral drama: You're not invited

By Andrew Osborn

LONDON (Reuters) - Britain will not invite Argentine President Cristina Fernandez to Margaret Thatcher's funeral next week in a snub likely to deepen a long-running diplomatic dispute over the Falkland Islands.

Thatcher, 87, who died on Monday, led Britain at the time of the 1982 Falklands war ordering her armed forces to repel an Argentine invasion of the contested South Atlantic archipelago which Argentina calls Las Malvinas.

Just over 30 years later, memories of the conflict remain raw and Fernandez has mounted a campaign to renegotiate the islands' sovereignty, lobbying Pope Francis on the issue and rejecting a referendum last month in which Falkland residents voted to remain a British Overseas Territory.

A government source told Reuters that every country with whom Britain enjoys "normal" diplomatic relations was being invited to Wednesday's funeral, but Thatcher's family had objected to Fernandez attending.

"It's about adhering to her family's wishes," the source said. A government spokesman said Argentina's ambassador to Britain would be invited, and that was in keeping with protocol.

The Daily Telegraph newspaper, without citing its sources, reported that Thatcher's children Mark and Carol said they felt it would be "inappropriate" for anyone from Argentina to be there after government officials floated the idea.

Argentine Foreign Minister Hector Timerman brushed off the apparent snub.

"It does not matter to me to be invited to a place where I don't want to go," he told a local radio station. "It is another provocation. The woman died, let the family mourn her in peace".

Prime Minister David Cameron's office made it clear on Thursday that invitations will be sent far and wide.

"Around 200 states, territories and international organisations are being invited to send an official representative to the funeral service," a spokesman said.

"We have invited those countries and institutions with whom we have normal diplomatic relations."

FALKLANDS THEME

Members of parliament from Thatcher's ruling Conservative party have hailed Britain's victory in the Falklands war as one of her greatest achievements and her funeral is expected to follow a Falklands theme.

More than 700 armed forces personnel will take part in the ceremony and the 10 coffin bearers will be drawn from regiments and units that played a pivotal role in the conflict.

The war boosted Thatcher's flagging political fortunes at the time and cemented her image as a patriotic defender of what was left of Britain's Empire, helping her win a landslide victory at a general election in 1983.

In a ceremonial funeral with military honours and attended by the Queen, Thatcher's coffin will be drawn on a gun carriage by six horses through London to a service at St Paul's Cathedral, a format that has drawn criticism from some politicians and commentators for its pomp and public expense.

Invitations to more than 2,000 guests will be sent out on Friday. Mikhail Gorbachev, 82, the last leader of the Soviet leader, will not be able to attend because of ill health, his spokesman said on Thursday.

Nancy Reagan, 91, the widow of Thatcher's great political U.S. ally Ronald Reagan, will also not be able to make the trip.

Cameron's office said those who have already said they will attend include former British Prime Minister Tony Blair, FW de Klerk, the last President of apartheid South Africa, and Canadian Prime Minister Stephen Harper.

It said invitations would be extended to all surviving British prime ministers and surviving former U.S. presidents, former U.S. secretary of state Hillary Clinton, European Commission President Jose Manuel Barroso and a representative of South Africa's Nelson Mandela, who is 94 and in poor health.

(Additional reporting by Steve Gutterman in Moscow and Alejandro Lifschitz in Buenos Aires; Editing by Guy Faulconbridge and Sonya Hepinstall)

Source: http://news.yahoo.com/britain-snubs-argentina-over-margaret-thatcher-funeral-092537571.html

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A Glimpse Of A Cultural Dystopia Without TV Broadcasters

zap-fox-anniversary-25-worst-shows-pictures-015An ominous “nuclear option” looms over the TV-loving American public if Fox and other broadcasters follow through with a threat to pull out of the public airwaves in response to Aereo, a brazen startup that streams TV signals online without paying providers. News reports are describing this as a “threat,” which, according to Merriam-Webster, is “an expression of intention to inflict evil, injury, or damage.” So let’s imagine that this high-unlikely bluff actually materializes. What kind of “evil” would befall the 14 percent of antenna-based TV viewers if they were deprived of such high-quality programming? Here’s a list of some of the best and worst shows over the last few decades: 1. Work It (2012) Described lovingly as a program that “could be the worst television show in history,”?Work It follows the cross-dressing antics of two men who disguise themselves as women, based on the evidently false premise that females are more employable in a recession. In the Work It universe, womanhood is a 24-hour vanity themed existence, hopping from eating disorders to discrimination to self-exploitation — all in a day. Nothing makes inequality and anorexia as enjoyable as laugh track. 2. Mr. Personality (2003) What’s better than desecrating the sacred institution of marriage in the depravity-demanding script of a reality TV show? Giving a platform to a woman at the center of possibly the most embarrassing political scandal in a century. In Mr. Personality, Monica Lewinsky–yes, that Monica Lewinsky, plays host to an attention-starved bachelorette, as a dozen masked men attempt to woo her into holy matrimony in the romantic time-span of a TV season. 3.?The Swan (2004) Nothing promotes America’s healthy gender attitudes like a show that rewards contestants for surgically?altering?their appearance for the approval of millions of strangers.?A team of coaches, therapists, surgeons and dentists literally create the soul-sucking contest of a beauty pageant out of thin broadcast air. The goal of?The?Swan, apparently, is to turn back the feminist clock to a time when we encouraged girls to look and, more importantly, think, like Barbie. Thoughtful readers might point out that canceled shows don’t fairly represent the richest offerings of the broadcast menu. What about the wildly popular shows? 4. Dancing With The Stars (Current) Childhood stars and scandal-ridden personalities cha-cha their way to attention heaven in a competition-reality show based on the premise that talent and moral bankruptcy can be overlooked in exchange for a few

Source: http://feedproxy.google.com/~r/Techcrunch/~3/fQ34qq316WQ/

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Thursday, April 11, 2013

Cuba to turn over Florida couple and children

This photo combination made from undated images provided by the Hillsborough County Sheriff's Office shows 35-year-old Joshua Michael Hakken, left, and his wife, 34-year-old Sharyn Patricia Hakken. Cuba says it will turn over to the United States the Florida couple who allegedly kidnapped their own children from the mother?s parents and fled by boat to Havana. (AP Photo/Hillsborough County Sheriff's Office)

This photo combination made from undated images provided by the Hillsborough County Sheriff's Office shows 35-year-old Joshua Michael Hakken, left, and his wife, 34-year-old Sharyn Patricia Hakken. Cuba says it will turn over to the United States the Florida couple who allegedly kidnapped their own children from the mother?s parents and fled by boat to Havana. (AP Photo/Hillsborough County Sheriff's Office)

A state security officer, in yellow, instructs journalists to stop making pictures of Joshua Hakken's blue sailboat, Salty, docked at the Hemingway Marina, in Havana, Cuba, Tuesday, April 9, 2013. Hakken and his wife Sharyn, who had lost custody of their two young boys, allegedly kidnapped them from Sharyn's parents and fled by boat to Havana. A foreign ministry official told The Associated Press in a written statement Tuesday that Cuba had informed U.S. authorities of the country's decision to turn over Hakken, his wife and their two young boys. She did not say when the handover would occur. (AP Photo/Peter Orsi)

This undated photo provided by the Hillsborough County Sheriff's Office shows a 25-foot sailboat that was recently acquired by Joshua Michael Hakken. Officials are searching for Hakken, who kidnapped his two children from their grandparents' home in Tampa, Fla. Hakken lost custody of the children last year after a drug possession arrest in Louisiana. (AP Photo/Hillsborough County Sheriff's Office)

This undated image provided by the Hillsborough County Sheriff's Office shows Sharyn Patricia Hakken. Authorities are searching for two young boys they believe were kidnapped by their father from their maternal grandparents' Florida home after their grandmother was tied up. The Hillsborough County Sheriff's Office on Wednesday night April 3, 2013 asked for the public's help in locating the boys, 4-year-old Cole Hakken and 2-year-old Chase Hakken. (AP Photo/Hillsborough County Sheriff's Office)

This undated image provided by the Hillsborough County Sheriff's Office shows 35-year-old Joshua Michael Hakken. Authorities are searching for two young boys they believe were kidnapped by their father from their maternal grandparents' Florida home after their grandmother was tied up. The Hillsborough County Sheriff's Office on Wednesday night April 3, 2013 asked for the public's help in locating the boys, 4-year-old Cole Hakken and 2-year-old Chase Hakken. The news release identified Hakken and the children's mother, 34-year-old Sharyn Patricia Hakken, as suspects in the abduction. (AP Photo/Hillsborough County Sheriff's Office)

(AP) ? Cuba said Tuesday that it will turn over to the United States a Florida couple who allegedly kidnapped their own children from the mother's parents and fled by boat to Havana, ending days of drama that evoked memories of the Elian Gonzalez custody battle of more than a decade ago.

Foreign Ministry official Johana Tablada told The Associated Press in a written statement Tuesday that Cuba had informed U.S. authorities of the country's decision to turn over Joshua Michael Hakken, his wife Sharyn, and their two young boys.

She did not say when the handover would occur, but reporters saw Sharyn Hakken leaving the dock of Havana's Hemingway Marina in the back seat of a Cuban government vehicle and workers later said that all four Hakkens had been taken away.

An AP reporter spotted the family earlier Tuesday beside their boat at the marina. A man who resembled photographs of Joshua Michael Hakken yelled out "Stop! Stay back!" as the reporter approached, but there was no outward sign of tension or distress between the family members.

Tablada said the Foreign Ministry had informed U.S. diplomats on the island "of the Cuban government's willingness to turn over ... U.S. citizens Joshua Michael Hakken, his wife Sharyn Patricia and their two minor sons."

She said Cuba tipped the State Department off to the Hakkens' presence on Sunday and that from that moment "diplomatic contact has been exchanged and a professional and constant communication has been maintained."

U.S. authorities say Hakken kidnapped his sons, 4-year-old Cole and 2-year-old Chase, from his mother-in-law's house north of Tampa. The boys' maternal grandparents had been granted permanent custody of the boys last week.

The U.S. and Cuba share no extradition agreement and the island nation is also not a signatory of the Hague Convention on the Civil Aspects of International Child Abduction, an international treaty for governmental cooperation on such cases.

Cuba has harbored U.S. fugitives in the past, though most of those cases date back to the 1960s and 70s, when the island became a refuge for members of the Black Panthers and other militant groups. More recently, dozens of Cuban Medicare fraud fugitives in the U.S. have tried to escape prosecution by returning to the island.

But Cuba has also cooperated with U.S. authorities in returning several criminal fugitives in recent years, including Leonard B. Auerbach in 2008. Auerbach was wanted in California on federal charges of sexually abusing a Costa Rican girl and possessing child pornography. He was deported.

In 2011, U.S. marshals flew to Cuba and took custody of two American suspects wanted in a New Jersey murder.

Hakken lost custody of his sons last year after a drug possession arrest in Louisiana and later tried to take the children from a foster home at gunpoint, authorities said. A warrant has been issued for his arrest on two counts of kidnapping; interference with child custody; child neglect; false imprisonment and other charges.

"My team and I working very hard to ensure safety for two Amcit kids," Conrad Tribble, the No. 2 U.S. diplomat on the island, said via Twitter later Tuesday, using a shorthand for "American citizens."

According to the Hillsborough County Sheriff's Office, Hakken entered his mother-in-law's Florida house last Wednesday, tied her up and fled with his sons. Federal, state and local authorities searched by air and sea for a boat Hakken had recently bought. The truck Hakken, his wife and the boys had been traveling in was found Thursday, abandoned in Madeira Beach, Florida.

"He'll have to face in Hillsborough county the charges he has with the sheriff's office," spokeswoman Cristal Bermudez Nunez Nunez said. She said she did not know how the family would be returned or what will happen when they arrive on U.S. soil.

Terri Durdaller, a spokeswoman at the Florida Department of Children and Families, said it was not clear where the children will ultimately be placed.

"Louisiana is the ultimate decision maker on where these children will reside. It's likely they will be placed back in Florida with the grandmother," she said.

The family's flight to Cuba harkened back to the 1999 child custody case involving Elian Gonzalez, though unlike Gonzalez, the Hakkens had no apparent ties to the island.

In 1999, 5-year-old Gonzalez was found clinging to an inner tube off Florida after his mother and others drowned while fleeing Cuba toward American soil. The boy was taken to Miami to live with relatives, but his father in Cuba demanded the boy be sent back.

U.S. courts ultimately ruled Gonzalez should be sent back, though his Miami relatives refused to return him. In April 2000, U.S. federal agents raided the family's home and he was returned to Cuba soon after. He has since grown into a young man and joined a military academy.

At the Havana marina on Tuesday, the family showed no sign they knew a decision about their fate had been made. The four strolled by an outdoor restaurant as security officials kept reporters at a distance.

The youngest child was seated in a stroller and the elder boy sat down on a curb. A woman who resembled Sharyn Hakken was seen on the boat.

Cuban officials told reporters not to take pictures of the family or the boat, which bore the name Salty and had a paw print on its side.

Andrew Zych, a Canadian docked in a sailboat steps away from the Hakkens, said the family had arrived recently and seemed normal.

"I liked the way they played with the kids," he said, adding he was surprised to learn of events in the U.S.

_____

Associated Press writers Christine Armario, Curt Anderson and Kelli Kennedy in Miami; Kevin McGill in New Orleans; and Matthew Lee in Washington contributed to this report.

_____

Paul Haven on Twitter: www.twitter.com/paulhaven

Follow Peter Orsi on Twitter: www.twitter.com/Peter_Orsi

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-09-US-Children-Kidnapped-Cuba/id-16a8ff0a0a724c8aabddb7d098202963

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EM ASIA FX-Won, Philippine peso top gainers as risk sentiment improves

* Weak Philippine exports data caps peso upside

* Won's upside limited on importers, N.Korea; missile eyed

* Ringgit cuts gains after 3-mth high with election date set

* S.Korea c.bank to cut rate on Thur; BI to hold rate

(Adds text, updates prices)

By Jongwoo Cheon

SINGAPORE, April 10 (Reuters) - The South Korean won and the

Philippine peso led emerging Asian currencies higher on

Wednesday as risk sentiment improved after strong China trade

data and a record Wall Street finish.

The Bank of Japan's bold easing programme also helped drive

up the Indonesian rupiah and the Malaysian ringgit

on views that investors will borrow a cheaper yen and

seek higher yields in Southeast Asia, traders said.

China's imports jumped 14.1 percent in March from a year

earlier, far exceeding expectations, indicating that domestic

demand in the world's second-largest economy was gathering steam

for a recovery.

"With risk appetite levels looking placid, markets may also

attempt to utilize any further indications of a global recovery

to channel into risk sensitive assets, especially if the FOMC

minutes tonight do not point to any urgency to tilt towards an

exit strategy," OCBC Bank said in a note.

The U.S. Federal Reserve is set to release the minutes of

the last monetary policy meeting and investors will look for

clues on whether the Fed would slow or halt its asset buying

stimulus.

In Asia, the central banks of South Korea and Indonesia are

scheduled to hold rate-setting meetings on Thursday. Bank of

Korea is expected to cut the interest rate, while Bank Indonesia

(BI) is seen leaving its benchmark rate unchanged, a pair of

Reuters poll showed.

PHILIPPINE PESO

The peso rose as interbank speculators covered short

positions, although data showing declining exports capped the

currency's upside, traders said.

Philippine exports fell for the second consecutive month in

February, posting the steepest drop in 14 months, casting doubt

on the government's first quarter growth forecast.

"It is more of temporary long dollar fix adjustment," said a

Philippine bank trader in Manila, referring to cutting bullish

dollar positions.

"But weak data may lead to an eventual weakening of the

peso," the trader said, adding the local currency is seen having

resistance around 41.10.

RUPIAH

The rupiah gained on bond inflows, although dollar demand

from corporates limited its gains, traders said.

BI was seen buying the rupiah from 9,710 per dollar, traders

added.

Investors are keeping an eye on whether BI tightens policy

by hiking the overnight deposit facility rate, called FASBI, to

help ease the country's current account deficit.

"BI should increase the FASBI rate this or next month,

although I think the next month is more possible," said a

Jakarta-based trader, adding the raise would support the rupiah.

WON

The won gained on demand from exporters' for settlements and

as local investors covered more short positions.

But its upside was capped by the geopolitical tension in the

peninsula and expectations of dollar demand linked to companies'

dividend payments to foreign shareholders.

South Korea said it has asked China, North Korea's only

major ally, to rein in the hermit state and has raised its

surveillance after the North moved at least one long-range

missile in readiness for a possible launch.

Local importers bought dollars for payments, traders said.

But some investors expected the won to rebound a bit more as

the currency is still seen excessively sold.

Seoul does not consider recent foreign capital outflows from

its markets to be a major cause for concern and that foreign

currency liquidity conditions remain stable, a senior finance

ministry official also said.

"The won is expected fall, probably to 1,145 per dollar, if

the North launches a missile, but it will quickly rebound.

Dollar long positions look still heavy," said a senior foreign

bank trader in Seoul.

The dollar/won's 14-day RSI stood at 70.4, still above the

70-threshold.

"I think the won saw a bottom, so it will be better to buy

the won whenever it falls," the trader added.

RINGGIT

The ringgit earlier hit 3.0180 to the U.S. dollar, its

strongest since Jan. 21, according to Thomson Reuters data, on

bond inflows and demand against the Singapore dollar.

The five-year government bond yield fell to 3.168

percent and the 10-year bond yield slid to 3.399

percent. Both were their lowest since late July last year.

But the Malaysian currency gave up most of earlier gains as

investors took profits after the country set May 5 as a date for

a general election.

Traders and analysts said the ringgit has priced a narrow

victory for the National Front led by Prime Minister Najib Razak

in. Opinion polls also suggest such a result.

CURRENCIES VS U.S. DOLLAR

Change on the day at 0645 GMT

Currency Latest bid Previous day Pct Move

Japan yen 99.09 99.04 -0.05

Sing dlr 1.2373 1.2395 +0.18

Taiwan dlr 29.982 30.050 +0.23

Korean won 1135.35 1139.40 +0.36

Baht 29.00 29.01 +0.03

Peso 41.13 41.27 +0.35

Rupiah 9695.00 9718.00 +0.24

Rupee 54.53 54.58 +0.10

Ringgit 3.0335 3.0370 +0.12

Yuan 6.1935 6.2024 +0.14

Change so far in 2013

Currency Latest bid End prev year Pct Move

Japan yen 99.09 86.79 -12.41

Sing dlr 1.2373 1.2219 -1.24

Taiwan dlr 29.982 29.136 -2.82

Korean won 1135.35 1070.60 -5.70

Baht 29.00 30.61 +5.55

Peso 41.13 41.05 -0.18

Rupiah 9695.00 9630.00 -0.67

Rupee 54.53 54.99 +0.85

Ringgit 3.0335 3.0580 +0.81

Yuan 6.1935 6.2303 +0.59

(Additional reporting by IFR Markets' Catherine Tan; Editing by

Sanjeev Miglani)

Source: http://news.yahoo.com/em-asia-fx-won-philippine-peso-top-gainers-074412266--finance.html

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Tuesday, April 9, 2013

Google searches about mental illness follow seasonal patterns

Google searches about mental illness follow seasonal patterns [ Back to EurekAlert! ] Public release date: 9-Apr-2013
[ | E-mail | Share Share ]

Contact: Brianna Lee
eAJPM@ucsd.edu
858-534-9407
Elsevier Health Sciences

New study in the American Journal of Preventive Medicine reports

San Diego, CA, April 9, 2013 A new study published in the May issue of the American Journal of Preventive Medicine finds that Google searches for information across all major mental illnesses and problems followed seasonal patterns, suggesting mental illness may be more strongly linked with seasonal patterns than previously thought.

Monitoring population mental illness trends has been an historic challenge for scientists and clinicians alike. Typically, telephone surveys are used to try to glimpse inside the minds of respondents, but this approach is limited because respondents may be reluctant to honestly discuss their mental health. This approach also has high material costs. As a result, investigators have not had the data they need.

"The Internet is a game changer," said lead investigator John W. Ayers, PhD, MA, of the Graduate School of Public Health at San Diego State University. "By passively monitoring how individuals search online we can figuratively look inside the heads of searchers to understand population mental health patterns."

Using Google's public database of queries, the study team identified and monitored mental health queries in the United States and Australia for 2006 through 2010. All queries relating to mental health were captured and then grouped by type of mental illness, including ADHD (attention deficit-hyperactivity disorder), anxiety, bipolar, depression, eating disorders (including anorexia or bulimia), OCD (obsessive compulsive disorder), schizophrenia, and suicide. Using advanced mathematical methods to identify trends, the authors found all mental health queries in both countries were consistently higher in winter than summer.

The research showed eating disorder searches were down 37 percent in summers versus winters in the U.S., and 42 percent in summers in Australia. Schizophrenia searches decreased 37 percent during U.S. summers and by 36 percent in Australia.

Bipolar searches were down 16 percent during U.S. summers and 17 percent during Australian summers; ADHD searches decreased by 28 percent in the U.S. and 31 percent in Australia during summertime. OCD searches were down 18 percent and 15 percent, and bipolar searches decreased by 18 percent and 16 percent, in the U.S. and Australia respectively.

Searches for suicide declined 24 and 29 percent during U.S. and Australian summers and anxiety searches had the smallest seasonal change down 7 percent during U.S. summers and 15 percent during Australian summers.

While some conditions, such as seasonal affective disorder, are known to be associated with seasonal weather patterns, the connections between seasons and a number of major disorders were surprising. "We didn't expect to find similar winter peaks and summer troughs for queries involving every specific mental illness or problem we studied, however, the results consistently showed seasonal effects across all conditions even after adjusting for media trends," said James Niels Rosenquist, MD, PhD, a psychiatrist at Massachusetts General Hospital.

"It is very exciting to ponder the potential for a universal mental health emollient, like Vitamin D (a metabolite of sun exposure). But it will be years before our findings are linked to serious mental illness and then linked to mechanisms that may be included in treatment and prevention programs," said Ayers. "Is it biologic, environmental, or social mechanisms explaining universal patterns in mental health information seeking? We don't know."

"Our findings can help researchers across the field of mental health generate additional new hypotheses while exploring other trends inexpensively in real-time," said Benjamin Althouse, a doctoral candidate at Johns Hopkins Bloomberg School of Public Health and researcher on the study. "For instance, moving forward, we can explore daily patterns in mental health information seeking maybe even finding a 'Monday effect.' The potential is limitless."

###

Dr. Daniel Ford, vice dean for clinical investigation in the Johns Hopkins University School of Medicine, and Jon-Patrick Allem, doctoral student at University of Southern California Keck School of Medicine, also contributed to the study.


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Google searches about mental illness follow seasonal patterns [ Back to EurekAlert! ] Public release date: 9-Apr-2013
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Contact: Brianna Lee
eAJPM@ucsd.edu
858-534-9407
Elsevier Health Sciences

New study in the American Journal of Preventive Medicine reports

San Diego, CA, April 9, 2013 A new study published in the May issue of the American Journal of Preventive Medicine finds that Google searches for information across all major mental illnesses and problems followed seasonal patterns, suggesting mental illness may be more strongly linked with seasonal patterns than previously thought.

Monitoring population mental illness trends has been an historic challenge for scientists and clinicians alike. Typically, telephone surveys are used to try to glimpse inside the minds of respondents, but this approach is limited because respondents may be reluctant to honestly discuss their mental health. This approach also has high material costs. As a result, investigators have not had the data they need.

"The Internet is a game changer," said lead investigator John W. Ayers, PhD, MA, of the Graduate School of Public Health at San Diego State University. "By passively monitoring how individuals search online we can figuratively look inside the heads of searchers to understand population mental health patterns."

Using Google's public database of queries, the study team identified and monitored mental health queries in the United States and Australia for 2006 through 2010. All queries relating to mental health were captured and then grouped by type of mental illness, including ADHD (attention deficit-hyperactivity disorder), anxiety, bipolar, depression, eating disorders (including anorexia or bulimia), OCD (obsessive compulsive disorder), schizophrenia, and suicide. Using advanced mathematical methods to identify trends, the authors found all mental health queries in both countries were consistently higher in winter than summer.

The research showed eating disorder searches were down 37 percent in summers versus winters in the U.S., and 42 percent in summers in Australia. Schizophrenia searches decreased 37 percent during U.S. summers and by 36 percent in Australia.

Bipolar searches were down 16 percent during U.S. summers and 17 percent during Australian summers; ADHD searches decreased by 28 percent in the U.S. and 31 percent in Australia during summertime. OCD searches were down 18 percent and 15 percent, and bipolar searches decreased by 18 percent and 16 percent, in the U.S. and Australia respectively.

Searches for suicide declined 24 and 29 percent during U.S. and Australian summers and anxiety searches had the smallest seasonal change down 7 percent during U.S. summers and 15 percent during Australian summers.

While some conditions, such as seasonal affective disorder, are known to be associated with seasonal weather patterns, the connections between seasons and a number of major disorders were surprising. "We didn't expect to find similar winter peaks and summer troughs for queries involving every specific mental illness or problem we studied, however, the results consistently showed seasonal effects across all conditions even after adjusting for media trends," said James Niels Rosenquist, MD, PhD, a psychiatrist at Massachusetts General Hospital.

"It is very exciting to ponder the potential for a universal mental health emollient, like Vitamin D (a metabolite of sun exposure). But it will be years before our findings are linked to serious mental illness and then linked to mechanisms that may be included in treatment and prevention programs," said Ayers. "Is it biologic, environmental, or social mechanisms explaining universal patterns in mental health information seeking? We don't know."

"Our findings can help researchers across the field of mental health generate additional new hypotheses while exploring other trends inexpensively in real-time," said Benjamin Althouse, a doctoral candidate at Johns Hopkins Bloomberg School of Public Health and researcher on the study. "For instance, moving forward, we can explore daily patterns in mental health information seeking maybe even finding a 'Monday effect.' The potential is limitless."

###

Dr. Daniel Ford, vice dean for clinical investigation in the Johns Hopkins University School of Medicine, and Jon-Patrick Allem, doctoral student at University of Southern California Keck School of Medicine, also contributed to the study.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/ehs-gsa040713.php

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